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Target Snapshot

CHEMBL614476 Target Snapshot

D283 Med · CELL-LINE · Homo sapiens

181Compounds
43Assays
32Approved Drugs
175.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats D283 Med as ChEMBL target CHEMBL614476. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
D283 Med
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614476
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD283 Med
UniProt AccessionN/A

D283 Med

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as D283 Med.

Review nameD283 Med
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
14
Phase III
14
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50175.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 10.08 IC50 0.084 Preclinical
CHEMBL65 8.49 IC50 3.198 Preclinical
CHEMBL3545252 8.21 IC50 6.239 Approved
CHEMBL1751 8.0 IC50 10.0 Approved
CHEMBL5440963 7.75 IC50 18.0 Preclinical
CHEMBL5440537 7.6 IC50 25.0 Preclinical
CHEMBL325041 7.42 IC50 37.79 Clinical
CHEMBL159 7.41 IC50 39.1 Approved
CHEMBL1972860 7.39 IC50 40.85 Clinical
CHEMBL1879463 7.3 IC50 49.61 Clinical
Distribution

pChEMBL Value Distribution

17
5.0
13
5.5
12
6.0
17
6.5
7
7.0
2
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
DIGOXIN
CHEMBL1751
Approved 1975
DOXORUBICIN
CHEMBL53463
Approved 1974
TRETINOIN
CHEMBL38
Approved 1971
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

43
Total Assays
158
Tested Compounds
1
Assay Types
Functional — 43 assays, 158 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 41 158 5.5
organism-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine