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Target Snapshot

CHEMBL614513 Target Snapshot

A10 · CELL-LINE · Rattus norvegicus

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120Compounds
103Assays
1Approved Drugs
47.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A10 as ChEMBL target CHEMBL614513. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A10
CELL-LINE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL614513
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether A10 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameA10
Target TypeCELL-LINE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelA10
UniProt AccessionN/A

A10

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as A10.

Review nameA10
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5027.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL39541 9.6 EC50 0.25 Clinical
CHEMBL501233 9.22 EC50 0.6 Preclinical
CHEMBL67 9.0 IC50 1.0 Preclinical
CHEMBL67 8.15 EC50 7.0 Preclinical
CHEMBL428647 7.42 IC50 38.0 Approved
CHEMBL1940255 7.4 IC50 40.0 Preclinical
CHEMBL507178 7.23 IC50 59.1 Preclinical
CHEMBL570493 7.16 IC50 70.0 Preclinical
CHEMBL566696 7.02 IC50 95.0 Preclinical
CHEMBL567969 6.89 IC50 130.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
7
5.5
2
6.0
8
6.5
5
7.0
1
7.5
2
8.0
0
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

103
Total Assays
17
Tested Compounds
2
Assay Types
Functional — 92 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 92 17 6.2
ADME — 11 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 16 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine