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Target Snapshot

CHEMBL614514 Target Snapshot

A204 · CELL-LINE · Homo sapiens

202Compounds
34Assays
29Approved Drugs
153.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A204 as ChEMBL target CHEMBL614514. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A204
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614514
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether A204 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelA204
UniProt AccessionN/A

A204

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as A204.

Review nameA204
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

29
Approved
9
Phase III
10
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50152.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL94657 8.51 IC50 3.12 Clinical
CHEMBL553025 8.49 IC50 3.208 Approved
CHEMBL46286 8.4 IC50 4.0 Approved
CHEMBL65 8.34 IC50 4.525 Preclinical
CHEMBL53463 8.19 IC50 6.482 Approved
CHEMBL2041933 8.07 IC50 8.562 Preclinical
CHEMBL159 8.06 IC50 8.765 Approved
CHEMBL1972860 8.05 IC50 8.848 Clinical
CHEMBL3545252 8.03 IC50 9.339 Approved
CHEMBL1289926 8.0 IC50 9.923 Approved
Distribution

pChEMBL Value Distribution

17
5.0
13
5.5
6
6.0
9
6.5
8
7.0
8
7.5
9
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEMIGATINIB
CHEMBL4297522
Approved 2020
MIDOSTAURIN
CHEMBL608533
Approved 2017
PALBOCICLIB
CHEMBL189963
Approved 2015
AXITINIB
CHEMBL1289926
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
OMACETAXINE MEPESUCCINATE
CHEMBL46286
Approved 2009
PAZOPANIB
CHEMBL477772
Approved 2009
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

34
Total Assays
114
Tested Compounds
2
Assay Types
Functional — 33 assays, 114 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 33 114 6.0
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine