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Target Snapshot

CHEMBL614518 Target Snapshot

A9 · CELL-LINE · Mus musculus

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67Compounds
12Assays
3Approved Drugs
28.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A9 as ChEMBL target CHEMBL614518. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A9
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614518
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether A9 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameA9
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelA9
UniProt AccessionN/A

A9

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as A9.

Review nameA9
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5012.0
EC5016.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL107 7.86 IC50 13.8 Approved
CHEMBL329817 7.86 IC50 13.8 Preclinical
CHEMBL300734 7.11 IC50 78.0 Preclinical
CHEMBL14 7.0 IC50 100.0 Approved
CHEMBL277014 6.96 IC50 110.0 Preclinical
CHEMBL557795 6.36 IC50 440.0 Preclinical
CHEMBL542065 6.11 IC50 780.0 Preclinical
CHEMBL12378 5.92 IC50 1200.0 Preclinical
CHEMBL7303 5.92 IC50 1200.0 Preclinical
CHEMBL538467 5.8 IC50 1600.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
3
5.5
2
6.0
1
6.5
2
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CARBACHOL
CHEMBL14
Approved 1972
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
25
Tested Compounds
2
Assay Types
Functional — 11 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 25 6.5
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine