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Target Snapshot

CHEMBL614519 Target Snapshot

ACHN · CELL-LINE · Homo sapiens

44,449Compounds
1,254Assays
35Approved Drugs
1,415.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ACHN as ChEMBL target CHEMBL614519. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ACHN
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614519
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ACHN still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelACHN
UniProt AccessionN/A

ACHN

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ACHN.

Review nameACHN
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

35
Approved
11
Phase III
13
Phase II
7
Phase I
Assay Mix

Activity Type Distribution

IC501,383.0
EC5032.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL150607 9.41 IC50 0.39 Preclinical
CHEMBL94657 9.13 IC50 0.7486 Clinical
CHEMBL18155 9.09 IC50 0.81 Preclinical
CHEMBL148576 9.0 IC50 1.0 Preclinical
CHEMBL215398 9.0 IC50 1.0 Preclinical
CHEMBL489463 9.0 IC50 1.0 Preclinical
CHEMBL53463 9.0 IC50 1.0 Approved
CHEMBL38957 8.89 IC50 1.28 Preclinical
CHEMBL374257 8.8 IC50 1.6 Preclinical
CHEMBL374481 8.8 IC50 1.6 Preclinical
Distribution

pChEMBL Value Distribution

281
5.0
253
5.5
119
6.0
67
6.5
48
7.0
19
7.5
21
8.0
6
8.5
7
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
AFATINIB
CHEMBL1173655
Approved 2013
BOSUTINIB
CHEMBL288441
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
DACTINOMYCIN
CHEMBL1554
Approved 1964
FLUOROURACIL
CHEMBL185
Approved 1962
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,254
Total Assays
769
Tested Compounds
2
Assay Types
Functional — 1,243 assays, 769 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,239 769 5.6
organism-based format 4 0
ADME — 11 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine