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Target Snapshot

CHEMBL614524 Target Snapshot

BaF3 · CELL-LINE · Mus musculus

2,557Compounds
1,495Assays
56Approved Drugs
4,128.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BaF3 as ChEMBL target CHEMBL614524. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BaF3
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614524
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BaF3 still has a stable protein naming contract across sources.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBaF3
UniProt AccessionN/A

BaF3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as BaF3.

Review nameBaF3
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

56
Approved
14
Phase III
21
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC503,909.0
EC50219.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5593035 11.0 IC50 0.01 Preclinical
CHEMBL5592071 10.96 IC50 0.011 Preclinical
CHEMBL5595676 10.89 IC50 0.013 Preclinical
CHEMBL5592293 10.82 IC50 0.015 Preclinical
CHEMBL5592796 10.66 IC50 0.022 Preclinical
CHEMBL5591001 10.62 IC50 0.024 Preclinical
CHEMBL113436 10.52 IC50 0.03 Preclinical
CHEMBL5193609 10.28 IC50 0.052 Preclinical
CHEMBL3545311 10.19 IC50 0.065 Approved
CHEMBL5593178 10.19 IC50 0.065 Preclinical
Distribution

pChEMBL Value Distribution

363
5.0
457
5.5
423
6.0
468
6.5
511
7.0
459
7.5
370
8.0
192
8.5
117
9.0
43
9.5
pChEMBL
Approved Drugs

Approved Drugs

LAZERTINIB
CHEMBL4558324
Approved 2024
MOMELOTINIB
CHEMBL1078178
Approved 2023
QUIZARTINIB
CHEMBL576982
Approved 2023
REPOTRECTINIB
CHEMBL4298138
Approved 2023
RITLECITINIB
CHEMBL4085457
Approved 2023
PACRITINIB
CHEMBL2035187
Approved 2022
INFIGRATINIB
CHEMBL1852688
Approved 2021
MOBOCERTINIB
CHEMBL4650319
Approved 2021
ASCIMINIB
CHEMBL4208229
Approved 2021
INFIGRATINIB PHOSPHATE
CHEMBL1834657
Approved 2021
SELUMETINIB
CHEMBL1614701
Approved 2020
SELPERCATINIB
CHEMBL4559134
Approved 2020
TEPOTINIB
CHEMBL3402762
Approved 2020
PRALSETINIB
CHEMBL4582651
Approved 2020
PEXIDARTINIB
CHEMBL3813873
Approved 2019
FEDRATINIB
CHEMBL1287853
Approved 2019
GILTERITINIB
CHEMBL3301622
Approved 2018
LAROTRECTINIB
CHEMBL3889654
Approved 2018
DACOMITINIB ANHYDROUS
CHEMBL2110732
Approved 2018
LORLATINIB
CHEMBL3286830
Approved 2018
AVATROMBOPAG
CHEMBL2103883
Approved 2018
BRIGATINIB
CHEMBL3545311
Approved 2017
NERATINIB
CHEMBL180022
Approved 2017
MIDOSTAURIN
CHEMBL608533
Approved 2017
OSIMERTINIB
CHEMBL3353410
Approved 2015
LENVATINIB
CHEMBL1289601
Approved 2015
CERITINIB
CHEMBL2403108
Approved 2014
AFATINIB
CHEMBL1173655
Approved 2013
CABOZANTINIB
CHEMBL2105717
Approved 2012
BOSUTINIB
CHEMBL288441
Approved 2012
TOFACITINIB
CHEMBL221959
Approved 2012
REGORAFENIB
CHEMBL1946170
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
RUXOLITINIB
CHEMBL1789941
Approved 2011
CRIZOTINIB
CHEMBL601719
Approved 2011
OMACETAXINE MEPESUCCINATE
CHEMBL46286
Approved 2009
NILOTINIB
CHEMBL255863
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
SUNITINIB
CHEMBL535
Approved 2006
DASATINIB ANHYDROUS
CHEMBL1421
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
ERLOTINIB
CHEMBL553
Approved 2004
GEFITINIB
CHEMBL939
Approved 2003
IMATINIB
CHEMBL941
Approved 2001
Assay Landscape

Assay Landscape

1,495
Total Assays
1,279
Tested Compounds
4
Assay Types
Functional — 1,410 assays, 1,279 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,226 1,279 7.1
organism-based format 184 0
ADME — 52 assays, 142 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 52 142 5.6
Toxicity — 32 assays, 39 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 39 6.2
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine