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Target Snapshot

CHEMBL614525 Target Snapshot

BeWo · CELL-LINE · Homo sapiens

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125Compounds
14Assays
3Approved Drugs
126.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BeWo as ChEMBL target CHEMBL614525. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BeWo
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614525
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BeWo still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeWo
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeWo
UniProt AccessionN/A

BeWo

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BeWo.

Review nameBeWo
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC50126.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428647 10.0 IC50 0.1 Approved
CHEMBL105 7.22 IC50 60.0 Approved
CHEMBL482353 6.44 IC50 360.0 Preclinical
CHEMBL471796 6.39 IC50 410.0 Preclinical
CHEMBL3809725 6.21 IC50 610.0 Preclinical
CHEMBL53463 5.97 IC50 1070.0 Approved
CHEMBL3327354 5.96 IC50 1090.0 Preclinical
CHEMBL3810244 5.96 IC50 1090.0 Preclinical
CHEMBL3809108 5.89 IC50 1300.0 Preclinical
CHEMBL5266999 5.8 IC50 1590.0 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
18
5.5
3
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
81
Tested Compounds
1
Assay Types
Functional — 14 assays, 81 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 81 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine