Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614527 Target Snapshot

BHK-21 · CELL-LINE · Mesocricetus auratus

Back to Search Search this target Browse approvals Evidence Card
538Compounds
88Assays
6Approved Drugs
206.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BHK-21 as ChEMBL target CHEMBL614527. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BHK-21
CELL-LINE · Mesocricetus auratus
As of 2026-09-13
ChEMBL target ID
CHEMBL614527
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BHK-21 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBHK-21
Target TypeCELL-LINE
OrganismMesocricetus auratus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBHK-21
UniProt AccessionN/A

BHK-21

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BHK-21.

Review nameBHK-21
OrganismMesocricetus auratus
Clinical Profile

Clinical Phase Distribution

6
Approved
Assay Mix

Activity Type Distribution

IC50151.0
EC5055.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL90555 8.82 IC50 1.51 Approved
CHEMBL866 7.4 EC50 40.0 Approved
CHEMBL178 7.05 IC50 90.0 Approved
CHEMBL220745 6.12 IC50 750.0 Preclinical
CHEMBL1223653 6.11 IC50 780.0 Preclinical
CHEMBL133490 6.1 EC50 800.0 Preclinical
CHEMBL4543692 6.05 IC50 900.0 Preclinical
CHEMBL4441645 6.0 IC50 1010.0 Preclinical
CHEMBL4439249 6.0 IC50 1010.0 Preclinical
CHEMBL4434896 6.0 IC50 1010.0 Preclinical
Distribution

pChEMBL Value Distribution

35
5.0
16
5.5
13
6.0
0
6.5
2
7.0
0
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
Properties Compare Identifier
DAUNORUBICIN
CHEMBL178
Approved 1979
Properties Compare Identifier
VINCRISTINE
CHEMBL90555
Approved 1963
Properties Compare Identifier
Assay Landscape

Assay Landscape

88
Total Assays
68
Tested Compounds
3
Assay Types
ADME — 36 assays, 49 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 36 49 4.9
Functional — 31 assays, 68 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 68 5.1
Toxicity — 21 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 1 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine