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Target Snapshot

CHEMBL614535 Target Snapshot

Calu-6 · CELL-LINE · Homo sapiens

327Compounds
143Assays
28Approved Drugs
219.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calu-6 as ChEMBL target CHEMBL614535. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calu-6
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614535
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calu-6 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalu-6
UniProt AccessionN/A

Calu-6

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Calu-6.

Review nameCalu-6
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
13
Phase III
13
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50190.0
EC5029.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1823147 9.8 IC50 0.16 Preclinical
CHEMBL5618885 9.52 IC50 0.3 Preclinical
CHEMBL5592018 9.22 IC50 0.6 Preclinical
CHEMBL67 9.03 IC50 0.94 Preclinical
CHEMBL325041 8.89 IC50 1.286 Clinical
CHEMBL888 8.76 IC50 1.735 Approved
CHEMBL3545252 8.35 IC50 4.474 Approved
CHEMBL96926 8.32 IC50 4.785 Preclinical
CHEMBL553025 8.24 IC50 5.701 Approved
CHEMBL94657 8.15 IC50 7.137 Clinical
Distribution

pChEMBL Value Distribution

39
5.0
18
5.5
15
6.0
12
6.5
5
7.0
0
7.5
6
8.0
2
8.5
2
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

147
Total Assays
192
Tested Compounds
2
Assay Types
Functional — 142 assays, 192 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 76 2 6.6
cell-based format 66 190 5.6
ADME — 5 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 7 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine