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Target Snapshot

CHEMBL614545 Target Snapshot

CEM-c113 · CELL-LINE · Homo sapiens

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36Compounds
4Assays
4Approved Drugs
28.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CEM-c113 as ChEMBL target CHEMBL614545. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CEM-c113
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614545
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CEM-c113 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCEM-c113
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCEM-c113
UniProt AccessionN/A

CEM-c113

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CEM-c113.

Review nameCEM-c113
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC5013.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL129 8.22 EC50 6.0 Approved
CHEMBL166784 8.05 EC50 9.0 Preclinical
CHEMBL352398 7.7 EC50 20.0 Preclinical
CHEMBL353179 7.7 EC50 20.0 Preclinical
CHEMBL440551 7.4 EC50 40.0 Preclinical
CHEMBL991 7.1 EC50 80.0 Approved
CHEMBL166614 7.0 EC50 100.0 Preclinical
CHEMBL170331 7.0 EC50 100.0 Preclinical
CHEMBL170006 6.92 EC50 120.0 Preclinical
CHEMBL424540 6.52 EC50 300.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
0
5.5
1
6.0
2
6.5
4
7.0
2
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

STAVUDINE
CHEMBL991
Approved 1994
Properties Compare Identifier
ZIDOVUDINE
CHEMBL129
Approved 1987
Properties Compare Identifier
Assay Landscape

Assay Landscape

4
Total Assays
12
Tested Compounds
1
Assay Types
Functional — 4 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 12 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine