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Target Snapshot

CHEMBL614547 Target Snapshot

CEM-DNR · CELL-LINE · Homo sapiens

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167Compounds
12Assays
1Approved Drugs
152.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CEM-DNR as ChEMBL target CHEMBL614547. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CEM-DNR
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614547
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CEM-DNR still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCEM-DNR
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCEM-DNR
UniProt AccessionN/A

CEM-DNR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CEM-DNR.

Review nameCEM-DNR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50152.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL330407 7.8 IC50 15.7 Preclinical
CHEMBL4541489 7.12 IC50 76.3 Preclinical
CHEMBL888 7.0 IC50 100.0 Approved
CHEMBL2322512 6.65 IC50 223.0 Preclinical
CHEMBL576300 6.57 IC50 270.0 Preclinical
CHEMBL67 6.5 IC50 319.0 Preclinical
CHEMBL4548174 6.31 IC50 490.0 Preclinical
CHEMBL4568280 6.31 IC50 490.0 Preclinical
CHEMBL5430486 6.31 IC50 490.0 Preclinical
CHEMBL5427078 6.28 IC50 520.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
13
5.5
6
6.0
3
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
120
Tested Compounds
1
Assay Types
Functional — 12 assays, 120 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 120 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine