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Target Snapshot

CHEMBL614548 Target Snapshot

CEM-SS · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
1,492Compounds
460Assays
13Approved Drugs
947.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CEM-SS as ChEMBL target CHEMBL614548. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CEM-SS
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614548
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CEM-SS still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCEM-SS
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCEM-SS
UniProt AccessionN/A

CEM-SS

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CEM-SS.

Review nameCEM-SS
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
1
Phase III
1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50525.0
EC50422.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL336441 10.57 EC50 0.027 Preclinical
CHEMBL137838 10.16 EC50 0.069 Preclinical
CHEMBL344257 10.14 EC50 0.072 Preclinical
CHEMBL141223 9.94 EC50 0.115 Preclinical
CHEMBL138969 9.82 EC50 0.15 Preclinical
CHEMBL338047 9.7 IC50 0.2 Preclinical
CHEMBL167617 9.62 EC50 0.24 Preclinical
CHEMBL329653 9.33 EC50 0.47 Preclinical
CHEMBL105916 9.33 EC50 0.47 Preclinical
CHEMBL319139 9.22 IC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

112
5.0
58
5.5
59
6.0
38
6.5
41
7.0
34
7.5
27
8.0
17
8.5
4
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

PLERIXAFOR
CHEMBL18442
Approved 2008
Properties Compare Identifier
ADEFOVIR DIPIVOXIL
CHEMBL922
Approved 2002
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
SAQUINAVIR
CHEMBL114
Approved 1995
Properties Compare Identifier
STAVUDINE
CHEMBL991
Approved 1994
Properties Compare Identifier
ZALCITABINE
CHEMBL853
Approved 1992
Properties Compare Identifier
ZIDOVUDINE
CHEMBL129
Approved 1987
Properties Compare Identifier
Assay Landscape

Assay Landscape

460
Total Assays
364
Tested Compounds
3
Assay Types
Functional — 371 assays, 364 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 371 364 5.9
ADME — 76 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 76 24 4.9
Toxicity — 13 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 2 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine