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Target Snapshot

CHEMBL614558 Target Snapshot

CHO-MG · CELL-LINE · Cricetulus griseus

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142Compounds
44Assays
0Approved Drugs
155.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CHO-MG as ChEMBL target CHEMBL614558. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CHO-MG
CELL-LINE · Cricetulus griseus
As of 2026-09-14
ChEMBL target ID
CHEMBL614558
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CHO-MG still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCHO-MG
Target TypeCELL-LINE
OrganismCricetulus griseus
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCHO-MG
UniProt AccessionN/A

CHO-MG

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CHO-MG.

Review nameCHO-MG
OrganismCricetulus griseus
Assay Mix

Activity Type Distribution

IC50155.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL558186 7.35 IC50 45.0 Preclinical
CHEMBL557403 7.13 IC50 74.0 Preclinical
CHEMBL543610 6.4 IC50 400.0 Preclinical
CHEMBL540552 6.35 IC50 450.0 Preclinical
CHEMBL542751 6.34 IC50 460.0 Preclinical
CHEMBL540336 6.22 IC50 600.0 Preclinical
CHEMBL258876 5.92 IC50 1200.0 Preclinical
CHEMBL537852 5.92 IC50 1200.0 Preclinical
CHEMBL4092941 5.62 IC50 2370.0 Preclinical
CHEMBL558813 5.6 IC50 2500.0 Preclinical
Distribution

pChEMBL Value Distribution

35
5.0
11
5.5
5
6.0
0
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

44
Total Assays
74
Tested Compounds
2
Assay Types
Functional — 29 assays, 74 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 29 74 4.9
ADME — 15 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 32 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine