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Target Snapshot

CHEMBL614573 Target Snapshot

H322 · CELL-LINE · Homo sapiens

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55Compounds
13Assays
0Approved Drugs
53.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H322 as ChEMBL target CHEMBL614573. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H322
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614573
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H322 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameH322
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH322
UniProt AccessionN/A

H322

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as H322.

Review nameH322
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5053.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL265841 8.0 IC50 10.0 Preclinical
CHEMBL441158 7.7 IC50 20.0 Preclinical
CHEMBL302778 6.41 IC50 390.0 Preclinical
CHEMBL5276794 6.34 IC50 460.0 Preclinical
CHEMBL4854283 6.1 IC50 790.0 Preclinical
CHEMBL4856977 6.1 IC50 790.0 Preclinical
CHEMBL4848341 6.03 IC50 940.0 Preclinical
CHEMBL4872477 6.0 IC50 1000.0 Preclinical
CHEMBL4875175 5.98 IC50 1050.0 Preclinical
CHEMBL4868464 5.92 IC50 1200.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
11
5.5
6
6.0
0
6.5
0
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
39
Tested Compounds
1
Assay Types
Functional — 13 assays, 39 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 39 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine