Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614576 Target Snapshot

H9c2 · CELL-LINE · Rattus norvegicus

Back to Search Search this target Browse approvals Evidence Card
2,648Compounds
672Assays
5Approved Drugs
1,940.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H9c2 as ChEMBL target CHEMBL614576. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H9c2
CELL-LINE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL614576
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H9c2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameH9c2
Target TypeCELL-LINE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH9c2
UniProt AccessionN/A

H9c2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as H9c2.

Review nameH9c2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC501,837.0
EC50103.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5282557 8.0 IC50 10.0 Preclinical
CHEMBL5071797 7.7 IC50 20.0 Preclinical
CHEMBL53463 7.7 IC50 19.95 Approved
CHEMBL5074752 7.52 IC50 30.0 Preclinical
CHEMBL217089 7.5 IC50 31.62 Preclinical
CHEMBL5571170 7.36 EC50 43.3 Preclinical
CHEMBL214168 7.2 IC50 63.1 Preclinical
CHEMBL3633556 7.16 EC50 68.6 Preclinical
CHEMBL5076249 6.85 IC50 140.0 Preclinical
CHEMBL5089009 6.85 IC50 140.0 Preclinical
Distribution

pChEMBL Value Distribution

117
5.0
28
5.5
11
6.0
5
6.5
3
7.0
5
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

672
Total Assays
521
Tested Compounds
3
Assay Types
Functional — 484 assays, 521 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 484 521 4.8
ADME — 106 assays, 119 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 106 119 5.0
Toxicity — 82 assays, 81 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 82 81 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine