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Target Snapshot

CHEMBL614582 Target Snapshot

HuTu80 · CELL-LINE · Homo sapiens

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181Compounds
52Assays
30Approved Drugs
156.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HuTu80 as ChEMBL target CHEMBL614582. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HuTu80
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614582
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HuTu80 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHuTu80
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuTu80
UniProt AccessionN/A

HuTu80

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HuTu80.

Review nameHuTu80
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

30
Approved
11
Phase III
10
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50152.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 10.78 IC50 0.01664 Approved
CHEMBL94657 9.48 IC50 0.3281 Clinical
CHEMBL325041 9.27 IC50 0.533 Clinical
CHEMBL96926 9.18 IC50 0.6572 Preclinical
CHEMBL1972860 9.1 IC50 0.7911 Clinical
CHEMBL428647 8.77 IC50 1.682 Approved
CHEMBL37061 8.72 IC50 1.9 Preclinical
CHEMBL53463 8.67 IC50 2.118 Approved
CHEMBL553025 8.66 IC50 2.177 Approved
CHEMBL18925 8.64 EC50 2.3 Preclinical
Distribution

pChEMBL Value Distribution

26
5.0
12
5.5
10
6.0
10
6.5
6
7.0
6
7.5
10
8.0
6
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

52
Total Assays
146
Tested Compounds
2
Assay Types
Functional — 51 assays, 146 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 51 146 6.1
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine