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Target Snapshot

CHEMBL614628 Target Snapshot

Raji · CELL-LINE · Homo sapiens

3,727Compounds
757Assays
26Approved Drugs
2,349.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Raji as ChEMBL target CHEMBL614628. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Raji
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614628
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Raji still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRaji
UniProt AccessionN/A

Raji

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Raji.

Review nameRaji
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

26
Approved
11
Phase III
15
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC501,550.0
EC50799.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4800456 10.52 IC50 0.03 Preclinical
CHEMBL4794117 10.3 IC50 0.05 Preclinical
CHEMBL5219900 9.8 EC50 0.16 Preclinical
CHEMBL3286729 9.49 IC50 0.32 Preclinical
CHEMBL3039502 9.44 IC50 0.36 Approved
CHEMBL5077508 9.4 IC50 0.4 Preclinical
CHEMBL380192 9.3 EC50 0.5 Preclinical
CHEMBL3827814 9.11 IC50 0.78 Preclinical
CHEMBL3818150 9.1 EC50 0.8 Preclinical
CHEMBL5220748 9.1 EC50 0.8 Preclinical
Distribution

pChEMBL Value Distribution

243
5.0
198
5.5
106
6.0
66
6.5
64
7.0
50
7.5
25
8.0
10
8.5
11
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

DUVELISIB
CHEMBL3039502
Approved 2018
IDELALISIB
CHEMBL2216870
Approved 2014
CERITINIB
CHEMBL2403108
Approved 2014
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
VINORELBINE
CHEMBL553025
Approved 1994
CLADRIBINE
CHEMBL1619
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
FLUDARABINE PHOSPHATE
CHEMBL1096882
Approved 1991
PODOFILOX
CHEMBL61
Approved 1990
DOXORUBICIN
CHEMBL53463
Approved 1974
DACTINOMYCIN
CHEMBL1554
Approved 1964
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

757
Total Assays
1,136
Tested Compounds
3
Assay Types
Functional — 575 assays, 1,136 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 545 1,136 5.6
organism-based format 30 0
ADME — 179 assays, 68 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 179 68 4.9
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine