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Target Snapshot

CHEMBL614629 Target Snapshot

Ramos · CELL-LINE · Homo sapiens

747Compounds
321Assays
12Approved Drugs
705.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ramos as ChEMBL target CHEMBL614629. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ramos
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614629
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ramos still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRamos
UniProt AccessionN/A

Ramos

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ramos.

Review nameRamos
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

12
Approved
5
Phase III
5
Phase II
Assay Mix

Activity Type Distribution

IC50589.0
EC50116.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2158589 10.82 IC50 0.015 Preclinical
CHEMBL2158588 10.74 IC50 0.018 Preclinical
CHEMBL2158596 10.66 IC50 0.022 Preclinical
CHEMBL888 10.52 EC50 0.03 Approved
CHEMBL2158598 10.33 IC50 0.047 Preclinical
CHEMBL2158597 10.3 IC50 0.05 Preclinical
CHEMBL2158590 10.1 IC50 0.08 Preclinical
CHEMBL2158591 10.05 IC50 0.09 Preclinical
CHEMBL5618885 9.52 IC50 0.3 Preclinical
CHEMBL98 9.28 IC50 0.52 Approved
Distribution

pChEMBL Value Distribution

143
5.0
74
5.5
47
6.0
23
6.5
31
7.0
29
7.5
11
8.0
10
8.5
3
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

TIRBANIBULIN
CHEMBL571546
Approved 2020
FOSTAMATINIB DISODIUM
CHEMBL3989516
Approved 2018
IBRUTINIB
CHEMBL1873475
Approved 2013
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
GEMCITABINE
CHEMBL888
Approved 1996
PACLITAXEL
CHEMBL428647
Approved 1992
FLOXURIDINE
CHEMBL917
Approved 1970
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

321
Total Assays
496
Tested Compounds
3
Assay Types
Functional — 319 assays, 496 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 303 496 5.8
organism-based format 16 0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine