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Target Snapshot

CHEMBL614637 Target Snapshot

KETR3 · CELL-LINE · Homo sapiens

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277Compounds
19Assays
3Approved Drugs
114.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KETR3 as ChEMBL target CHEMBL614637. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KETR3
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614637
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KETR3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKETR3
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKETR3
UniProt AccessionN/A

KETR3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KETR3.

Review nameKETR3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC50114.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1946680 8.79 IC50 1.61 Preclinical
CHEMBL5196001 8.67 IC50 2.12 Preclinical
CHEMBL1946681 8.52 IC50 3.01 Preclinical
CHEMBL1946532 8.44 IC50 3.63 Preclinical
CHEMBL84 8.31 IC50 4.9 Approved
CHEMBL1946534 8.16 IC50 6.88 Preclinical
CHEMBL452709 8.02 IC50 9.56 Preclinical
CHEMBL1946362 7.96 IC50 11.01 Preclinical
CHEMBL1946361 7.94 IC50 11.49 Preclinical
CHEMBL1946531 7.89 IC50 12.94 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
9
5.5
1
6.0
3
6.5
7
7.0
10
7.5
4
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

19
Total Assays
72
Tested Compounds
1
Assay Types
Functional — 19 assays, 72 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 72 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine