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Target Snapshot

CHEMBL614654 Target Snapshot

FHC · CELL-LINE · Homo sapiens

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124Compounds
27Assays
4Approved Drugs
46.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats FHC as ChEMBL target CHEMBL614654. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
FHC
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614654
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether FHC still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameFHC
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFHC
UniProt AccessionN/A

FHC

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as FHC.

Review nameFHC
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5046.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL359744 7.24 IC50 57.0 Approved
CHEMBL4472209 6.27 IC50 540.0 Preclinical
CHEMBL4278178 6.2 IC50 630.0 Preclinical
CHEMBL4294165 6.17 IC50 670.0 Preclinical
CHEMBL4282880 5.99 IC50 1020.0 Preclinical
CHEMBL4587222 5.93 IC50 1180.0 Preclinical
CHEMBL4298697 5.81 IC50 1560.0 Preclinical
CHEMBL4759112 5.81 IC50 1550.0 Preclinical
CHEMBL98 5.59 IC50 2590.0 Approved
CHEMBL563939 5.55 IC50 2810.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
6
5.5
3
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

27
Total Assays
16
Tested Compounds
3
Assay Types
ADME — 16 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 16 5.6
Toxicity — 9 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 5 5.1
Functional — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 2 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine