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Target Snapshot

CHEMBL614657 Target Snapshot

C6 · CELL-LINE · Rattus norvegicus

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1,255Compounds
547Assays
15Approved Drugs
762.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C6 as ChEMBL target CHEMBL614657. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C6
CELL-LINE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL614657
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C6 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameC6
Target TypeCELL-LINE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC6
UniProt AccessionN/A

C6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C6.

Review nameC6
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

15
Approved
3
Phase III
1
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50642.0
KI6.0
EC50114.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL223643 9.4 IC50 0.4 Preclinical
CHEMBL3099816 8.62 IC50 2.4 Preclinical
CHEMBL3099598 8.54 IC50 2.9 Preclinical
CHEMBL3343410 7.6 Ki 25.0 Preclinical
CHEMBL98745 7.55 IC50 28.0 Preclinical
CHEMBL359744 7.22 IC50 60.0 Approved
CHEMBL3341777 7.11 Ki 77.0 Preclinical
CHEMBL1391713 7.0 IC50 100.0 Preclinical
CHEMBL53463 7.0 IC50 100.0 Approved
CHEMBL112914 6.92 IC50 120.0 Preclinical
Distribution

pChEMBL Value Distribution

100
5.0
62
5.5
42
6.0
24
6.5
5
7.0
3
7.5
0
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

547
Total Assays
394
Tested Compounds
3
Assay Types
Functional — 504 assays, 394 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 442 394 5.3
organism-based format 62 0 —
ADME — 31 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 11 4.2
Toxicity — 12 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 2 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine