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Target Snapshot

CHEMBL614691 Target Snapshot

LLC-MK2 · CELL-LINE · Macaca mulatta

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278Compounds
39Assays
4Approved Drugs
41.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LLC-MK2 as ChEMBL target CHEMBL614691. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LLC-MK2
CELL-LINE · Macaca mulatta
As of 2026-09-14
ChEMBL target ID
CHEMBL614691
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LLC-MK2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLLC-MK2
Target TypeCELL-LINE
OrganismMacaca mulatta
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLLC-MK2
UniProt AccessionN/A

LLC-MK2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as LLC-MK2.

Review nameLLC-MK2
OrganismMacaca mulatta
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5026.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL10557 8.64 IC50 2.3 Preclinical
CHEMBL3431410 6.35 IC50 446.68 Preclinical
CHEMBL5186029 5.02 EC50 9600.0 Preclinical
CHEMBL3581921 5.0 IC50 10000.0 Preclinical
CHEMBL5171305 4.88 EC50 13030.0 Preclinical
CHEMBL1077544 4.66 IC50 22000.0 Preclinical
CHEMBL5186410 4.6 EC50 25070.0 Preclinical
CHEMBL5175912 4.59 EC50 25700.0 Preclinical
CHEMBL55 4.59 IC50 25610.0 Approved
CHEMBL3581919 4.58 IC50 26000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

39
Total Assays
19
Tested Compounds
3
Assay Types
ADME — 23 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 19 4.4
Functional — 8 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 1 8.6
Toxicity — 8 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 13 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine