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Target Snapshot

CHEMBL614720 Target Snapshot

L5178Y · CELL-LINE · Mus musculus

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987Compounds
275Assays
6Approved Drugs
948.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L5178Y as ChEMBL target CHEMBL614720. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L5178Y
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL614720
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L5178Y still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameL5178Y
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL5178Y
UniProt AccessionN/A

L5178Y

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as L5178Y.

Review nameL5178Y
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

6
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50881.0
EC5067.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL917 9.12 IC50 0.76 Approved
CHEMBL886 8.85 IC50 1.4 Preclinical
CHEMBL3143430 8.7 IC50 2.0 Preclinical
CHEMBL376876 8.7 IC50 2.0 Preclinical
CHEMBL4171151 8.49 IC50 3.23 Preclinical
CHEMBL4170350 8.26 IC50 5.48 Preclinical
CHEMBL479 8.13 IC50 7.43 Approved
CHEMBL5191397 8.12 IC50 7.5 Preclinical
CHEMBL4170784 8.02 IC50 9.49 Preclinical
CHEMBL4159046 8.01 IC50 9.68 Preclinical
Distribution

pChEMBL Value Distribution

80
5.0
39
5.5
20
6.0
11
6.5
28
7.0
33
7.5
14
8.0
6
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VERAPAMIL
CHEMBL6966
Approved 1981
Properties Compare Identifier
DAUNORUBICIN
CHEMBL178
Approved 1979
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
FLOXURIDINE
CHEMBL917
Approved 1970
Properties Compare Identifier
THIORIDAZINE
CHEMBL479
Approved 1962
Properties Compare Identifier
Assay Landscape

Assay Landscape

275
Total Assays
262
Tested Compounds
3
Assay Types
Functional — 215 assays, 262 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 213 262 5.3
organism-based format 2 0 —
Toxicity — 32 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 0 —
ADME — 28 assays, 41 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 28 41 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine