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Target Snapshot

CHEMBL614775 Target Snapshot

T98G · CELL-LINE · Homo sapiens

1,095Compounds
324Assays
29Approved Drugs
778.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats T98G as ChEMBL target CHEMBL614775. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
T98G
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614775
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether T98G still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelT98G
UniProt AccessionN/A

T98G

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as T98G.

Review nameT98G
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

29
Approved
11
Phase III
11
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50710.0
EC5068.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3735275 9.3 EC50 0.5 Preclinical
CHEMBL96926 9.13 IC50 0.7406 Preclinical
CHEMBL1630582 9.0 IC50 1.0 Preclinical
CHEMBL1725990 9.0 IC50 1.0 Preclinical
CHEMBL1987055 9.0 IC50 1.0 Preclinical
CHEMBL1630581 8.96 IC50 1.099 Preclinical
CHEMBL1970209 8.96 IC50 1.099 Preclinical
CHEMBL534423 8.96 IC50 1.1 Preclinical
CHEMBL3545252 8.93 IC50 1.17 Approved
CHEMBL2398330 8.73 IC50 1.85 Preclinical
Distribution

pChEMBL Value Distribution

87
5.0
64
5.5
62
6.0
42
6.5
34
7.0
29
7.5
21
8.0
9
8.5
5
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
ABEMACICLIB
CHEMBL3301610
Approved 2017
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
NICLOSAMIDE
CHEMBL1448
Approved 1982
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

324
Total Assays
619
Tested Compounds
4
Assay Types
Functional — 301 assays, 619 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 301 619 5.6
ADME — 19 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 4 5.2
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine