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Target Snapshot

CHEMBL614780 Target Snapshot

Pancreatic beta cell · CELL-LINE

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43Compounds
25Assays
0Approved Drugs
18.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Pancreatic beta cell as ChEMBL target CHEMBL614780. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Pancreatic beta cell
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL614780
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Pancreatic beta cell still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePancreatic beta cell
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPancreatic beta cell
UniProt AccessionN/A

Pancreatic beta cell

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Pancreatic beta cell.

Review namePancreatic beta cell
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC507.0
EC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4640031 6.92 EC50 120.0 Preclinical
CHEMBL4647659 6.72 EC50 190.0 Preclinical
CHEMBL4636064 6.68 EC50 210.0 Preclinical
CHEMBL99203 6.51 EC50 310.0 Preclinical
CHEMBL4638292 6.12 EC50 760.0 Preclinical
CHEMBL377467 5.5 IC50 3130.0 Preclinical
CHEMBL373788 5.44 IC50 3600.0 Preclinical
CHEMBL378033 5.43 IC50 3670.0 Preclinical
CHEMBL425784 5.42 IC50 3850.0 Preclinical
CHEMBL209643 5.39 IC50 4060.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
1
5.5
5
6.0
4
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

25
Total Assays
12
Tested Compounds
1
Assay Types
Functional — 25 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 12 6.0
assay format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine