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Target Snapshot

CHEMBL614781 Target Snapshot

BV-2 · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
2,140Compounds
1,116Assays
6Approved Drugs
1,506.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BV-2 as ChEMBL target CHEMBL614781. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BV-2
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614781
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BV-2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBV-2
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBV-2
UniProt AccessionN/A

BV-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BV-2.

Review nameBV-2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

6
Approved
6
Phase III
12
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC501,491.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4212418 8.47 IC50 3.4 Preclinical
CHEMBL2017441 8.1 IC50 8.0 Preclinical
CHEMBL2017441 7.7 EC50 20.0 Preclinical
CHEMBL3775246 7.7 IC50 20.0 Preclinical
CHEMBL3775928 7.52 IC50 30.0 Preclinical
CHEMBL4208120 7.52 IC50 30.0 Preclinical
CHEMBL4476753 7.16 IC50 70.0 Preclinical
CHEMBL3774597 7.1 IC50 80.0 Preclinical
CHEMBL252370 7.08 IC50 84.0 Preclinical
CHEMBL4209314 7.05 IC50 90.0 Preclinical
Distribution

pChEMBL Value Distribution

241
5.0
100
5.5
38
6.0
5
6.5
6
7.0
5
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1,116
Total Assays
897
Tested Compounds
3
Assay Types
Functional — 919 assays, 897 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 919 897 4.9
ADME — 127 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 127 11 4.5
Toxicity — 70 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 70 61 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine