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Target Snapshot

CHEMBL614802 Target Snapshot

H2981 cell line · CELL-LINE · Homo sapiens

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12Compounds
10Assays
2Approved Drugs
49.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H2981 cell line as ChEMBL target CHEMBL614802. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H2981 cell line
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614802
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H2981 cell line still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameH2981 cell line
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH2981 cell line
UniProt AccessionN/A

H2981 cell line

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as H2981 cell line.

Review nameH2981 cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5049.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL282621 10.92 IC50 0.012 Preclinical
CHEMBL283005 10.62 IC50 0.024 Preclinical
CHEMBL282534 10.41 IC50 0.039 Preclinical
CHEMBL263250 9.89 IC50 0.13 Preclinical
CHEMBL406975 9.41 IC50 0.39 Preclinical
CHEMBL28740 8.01 IC50 9.86 Preclinical
CHEMBL353060 6.7 IC50 200.0 Preclinical
CHEMBL53463 6.3 IC50 500.0 Approved
CHEMBL353928 6.16 IC50 700.0 Preclinical
CHEMBL435911 5.3 IC50 5000.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
2
5.5
15
6.0
2
6.5
0
7.0
2
7.5
3
8.0
3
8.5
2
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

10
Total Assays
12
Tested Compounds
1
Assay Types
Functional — 10 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 12 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine