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Target Snapshot

CHEMBL614817 Target Snapshot

HEC-1B cell line · CELL-LINE · Homo sapiens

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34Compounds
14Assays
3Approved Drugs
32.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HEC-1B cell line as ChEMBL target CHEMBL614817. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HEC-1B cell line
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614817
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HEC-1B cell line still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHEC-1B cell line
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHEC-1B cell line
UniProt AccessionN/A

HEC-1B cell line

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HEC-1B cell line.

Review nameHEC-1B cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5031.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1090479 8.4 EC50 4.0 Preclinical
CHEMBL65 7.22 IC50 60.0 Preclinical
CHEMBL1094636 6.9 IC50 127.0 Approved
CHEMBL419007 6.72 IC50 190.0 Preclinical
CHEMBL420670 6.17 IC50 670.0 Preclinical
CHEMBL5396419 5.94 IC50 1160.0 Preclinical
CHEMBL108508 5.68 IC50 2110.0 Preclinical
CHEMBL111658 5.57 IC50 2710.0 Preclinical
CHEMBL4859726 5.52 IC50 3000.0 Preclinical
CHEMBL109188 5.48 IC50 3290.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
4
5.5
1
6.0
2
6.5
1
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIRAPARIB
CHEMBL1094636
Approved 2017
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
28
Tested Compounds
1
Assay Types
Functional — 14 assays, 28 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 28 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine