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Target Snapshot

CHEMBL614828 Target Snapshot

HN5 · CELL-LINE · Homo sapiens

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100Compounds
32Assays
4Approved Drugs
97.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HN5 as ChEMBL target CHEMBL614828. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HN5
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614828
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HN5 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHN5
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHN5
UniProt AccessionN/A

HN5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HN5.

Review nameHN5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
1
Phase I
Assay Mix

Activity Type Distribution

IC5083.0
EC5014.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2204502 8.26 IC50 5.5 Preclinical
CHEMBL939 8.0 EC50 10.0 Approved
CHEMBL1090479 8.0 EC50 10.0 Preclinical
CHEMBL1201179 7.82 EC50 15.0 Approved
CHEMBL554 7.6 IC50 25.0 Approved
CHEMBL504034 7.52 EC50 30.0 Preclinical
CHEMBL495734 7.43 IC50 37.0 Preclinical
CHEMBL31965 7.3 EC50 50.0 Clinical
CHEMBL500381 7.28 IC50 52.0 Preclinical
CHEMBL466586 7.24 IC50 58.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
11
5.5
24
6.0
27
6.5
17
7.0
3
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LAPATINIB DITOSYLATE
CHEMBL1201179
Approved 2007
Properties Compare Identifier
LAPATINIB
CHEMBL554
Approved 2007
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
Assay Landscape

Assay Landscape

32
Total Assays
87
Tested Compounds
1
Assay Types
Functional — 32 assays, 87 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 87 6.5
organism-based format 5 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine