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Target Snapshot

CHEMBL614830 Target Snapshot

HONE1 cell line · CELL-LINE · Homo sapiens

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82Compounds
45Assays
0Approved Drugs
76.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HONE1 cell line as ChEMBL target CHEMBL614830. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HONE1 cell line
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614830
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HONE1 cell line still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHONE1 cell line
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHONE1 cell line
UniProt AccessionN/A

HONE1 cell line

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HONE1 cell line.

Review nameHONE1 cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase I
Assay Mix

Activity Type Distribution

IC5076.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL9011 8.52 IC50 3.0 Preclinical
CHEMBL67 8.4 IC50 4.0 Preclinical
CHEMBL17289 7.82 IC50 15.0 Preclinical
CHEMBL9309 7.64 IC50 23.0 Preclinical
CHEMBL336442 7.22 IC50 60.0 Preclinical
CHEMBL8953 7.19 IC50 64.5 Preclinical
CHEMBL341709 7.16 IC50 70.0 Preclinical
CHEMBL5279559 7.16 IC50 70.0 Preclinical
CHEMBL276625 7.06 IC50 87.0 Preclinical
CHEMBL343222 6.89 IC50 130.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
4
5.5
13
6.0
7
6.5
7
7.0
3
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

45
Total Assays
55
Tested Compounds
1
Assay Types
Functional — 45 assays, 55 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 45 55 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine