Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614877 Target Snapshot

NCI · CELL-LINE

Back to Search Search this target Browse approvals Evidence Card
109Compounds
35Assays
1Approved Drugs
65.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI as ChEMBL target CHEMBL614877. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL614877
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI
UniProt AccessionN/A

NCI

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI.

Review nameNCI
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5065.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL395497 8.09 IC50 8.2 Preclinical
CHEMBL226880 8.01 IC50 9.8 Preclinical
CHEMBL131549 7.0 IC50 100.0 Preclinical
CHEMBL133389 7.0 IC50 100.0 Preclinical
CHEMBL133394 7.0 IC50 100.0 Preclinical
CHEMBL422982 7.0 IC50 100.0 Preclinical
CHEMBL364447 6.8 IC50 160.0 Clinical
CHEMBL390452 6.72 IC50 190.0 Preclinical
CHEMBL242533 6.48 IC50 330.0 Preclinical
CHEMBL129941 6.0 IC50 1000.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
4
5.5
13
6.0
2
6.5
4
7.0
0
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

35
Total Assays
43
Tested Compounds
1
Assay Types
Functional — 35 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 35 43 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine