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Target Snapshot

CHEMBL614891 Target Snapshot

S49 · CELL-LINE · Mus musculus

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35Compounds
23Assays
1Approved Drugs
28.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats S49 as ChEMBL target CHEMBL614891. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
S49
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614891
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether S49 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameS49
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelS49
UniProt AccessionN/A

S49

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as S49.

Review nameS49
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

EC5028.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL195535 7.52 EC50 30.0 Preclinical
CHEMBL448290 6.6 EC50 250.0 Preclinical
CHEMBL2448164 5.48 EC50 3300.0 Preclinical
CHEMBL3228720 5.22 EC50 6000.0 Preclinical
CHEMBL1425 5.1 EC50 8000.0 Approved
CHEMBL3228718 5.0 EC50 10000.0 Preclinical
CHEMBL3228719 5.0 EC50 10000.0 Preclinical
CHEMBL3228716 4.64 EC50 23000.0 Preclinical
CHEMBL3228717 4.48 EC50 33000.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
0
5.5
0
6.0
1
6.5
1
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

23
Total Assays
14
Tested Compounds
1
Assay Types
Functional — 23 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 14 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine