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Target Snapshot

CHEMBL614908 Target Snapshot

SF-295 · CELL-LINE · Homo sapiens

43,770Compounds
1,042Assays
30Approved Drugs
713.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SF-295 as ChEMBL target CHEMBL614908. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SF-295
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614908
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SF-295 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSF-295
UniProt AccessionN/A

SF-295

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as SF-295.

Review nameSF-295
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

30
Approved
9
Phase III
12
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50693.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1683552 10.0 IC50 0.1 Preclinical
CHEMBL1683545 9.59 IC50 0.26 Preclinical
CHEMBL96926 9.48 IC50 0.3319 Preclinical
CHEMBL1683556 9.39 IC50 0.41 Preclinical
CHEMBL4636420 9.35 EC50 0.45 Preclinical
CHEMBL18155 9.29 IC50 0.51 Preclinical
CHEMBL150607 9.23 IC50 0.59 Preclinical
CHEMBL4648960 8.96 EC50 1.1 Preclinical
CHEMBL94657 8.72 IC50 1.918 Clinical
CHEMBL38957 8.58 IC50 2.64 Preclinical
Distribution

pChEMBL Value Distribution

91
5.0
100
5.5
73
6.0
25
6.5
15
7.0
11
7.5
3
8.0
4
8.5
5
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
ERIBULIN MESYLATE
CHEMBL1683544
Approved 2010
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
AMSACRINE
CHEMBL43
Approved 1987
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
FLUOROURACIL
CHEMBL185
Approved 1962
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,042
Total Assays
414
Tested Compounds
3
Assay Types
Functional — 1,030 assays, 414 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,021 414 5.7
organism-based format 9 0
ADME — 9 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0
Unassigned — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine