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Target Snapshot

CHEMBL614922 Target Snapshot

SK-MEL-5 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
42,905Compounds
1,096Assays
9Approved Drugs
253.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SK-MEL-5 as ChEMBL target CHEMBL614922. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SK-MEL-5
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614922
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SK-MEL-5 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSK-MEL-5
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSK-MEL-5
UniProt AccessionN/A

SK-MEL-5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SK-MEL-5.

Review nameSK-MEL-5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

9
Approved
3
Phase III
7
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50238.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL150607 9.19 IC50 0.64 Preclinical
CHEMBL4636420 9.13 EC50 0.74 Preclinical
CHEMBL4648960 9.1 EC50 0.8 Preclinical
CHEMBL38957 8.96 IC50 1.11 Preclinical
CHEMBL5284857 8.59 IC50 2.6 Preclinical
CHEMBL4633528 8.55 EC50 2.8 Preclinical
CHEMBL4635291 8.55 EC50 2.8 Preclinical
CHEMBL2105734 8.4 IC50 4.0 Clinical
CHEMBL18155 8.33 IC50 4.7 Preclinical
CHEMBL560895 8.22 IC50 6.0 Preclinical
Distribution

pChEMBL Value Distribution

37
5.0
43
5.5
18
6.0
14
6.5
22
7.0
6
7.5
6
8.0
4
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
FLUOROURACIL
CHEMBL185
Approved 1962
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,096
Total Assays
211
Tested Compounds
3
Assay Types
Functional — 1,087 assays, 211 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,080 210 5.9
organism-based format 7 1 5.2
ADME — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine