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Target Snapshot

CHEMBL614924 Target Snapshot

SK-N-SH · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
962Compounds
333Assays
8Approved Drugs
637.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SK-N-SH as ChEMBL target CHEMBL614924. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SK-N-SH
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614924
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SK-N-SH still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSK-N-SH
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSK-N-SH
UniProt AccessionN/A

SK-N-SH

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SK-N-SH.

Review nameSK-N-SH
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
2
Phase III
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50528.0
EC50109.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1836544 10.92 IC50 0.012 Preclinical
CHEMBL1836543 10.9 IC50 0.0125 Preclinical
CHEMBL1836542 10.89 IC50 0.0128 Preclinical
CHEMBL1836549 10.78 IC50 0.0166 Preclinical
CHEMBL1836541 10.73 IC50 0.0188 Preclinical
CHEMBL1836547 10.68 IC50 0.0209 Preclinical
CHEMBL1836545 10.68 IC50 0.0207 Preclinical
CHEMBL1836550 10.45 IC50 0.0358 Preclinical
CHEMBL1836551 10.44 IC50 0.0362 Preclinical
CHEMBL165 10.39 IC50 0.0403 Clinical
Distribution

pChEMBL Value Distribution

142
5.0
55
5.5
52
6.0
30
6.5
8
7.0
5
7.5
0
8.0
1
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ALECTINIB
CHEMBL1738797
Approved 2015
Properties Compare Identifier
CERITINIB
CHEMBL2403108
Approved 2014
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

333
Total Assays
530
Tested Compounds
3
Assay Types
Functional — 308 assays, 530 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 308 530 5.4
ADME — 17 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 13 4.4
Toxicity — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine