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Target Snapshot

CHEMBL614942 Target Snapshot

SW 1116 · CELL-LINE · Homo sapiens

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141Compounds
9Assays
14Approved Drugs
143.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW 1116 as ChEMBL target CHEMBL614942. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW 1116
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614942
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW 1116 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW 1116
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW 1116
UniProt AccessionN/A

SW 1116

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW 1116.

Review nameSW 1116
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

14
Approved
6
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50143.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4436031 8.82 IC50 1.5 Preclinical
CHEMBL4451053 8.82 IC50 1.5 Preclinical
CHEMBL136985 8.74 IC50 1.8 Preclinical
CHEMBL4435499 8.51 IC50 3.1 Preclinical
CHEMBL1080066 7.92 IC50 12.0 Preclinical
CHEMBL4459598 7.48 IC50 33.0 Preclinical
CHEMBL5400793 7.47 IC50 34.0 Preclinical
CHEMBL509175 7.41 IC50 39.0 Preclinical
CHEMBL507361 7.22 IC50 60.49 Clinical
CHEMBL575448 7.17 IC50 67.0 Clinical
Distribution

pChEMBL Value Distribution

22
5.0
11
5.5
2
6.0
6
6.5
6
7.0
1
7.5
0
8.0
4
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
Assay Landscape

Assay Landscape

11
Total Assays
119
Tested Compounds
1
Assay Types
Functional — 11 assays, 119 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 119 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine