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Target Snapshot

CHEMBL614965 Target Snapshot

Clostridioides difficile · ORGANISM · Clostridioides difficile

Back to Search Search this target Browse approvals Evidence Card
1,244Compounds
1,032Assays
1Approved Drugs
94.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Clostridioides difficile as ChEMBL target CHEMBL614965. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Clostridioides difficile
ORGANISM · Clostridioides difficile
As of 2026-09-14
ChEMBL target ID
CHEMBL614965
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Clostridioides difficile still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameClostridioides difficile
Target TypeORGANISM
OrganismClostridioides difficile
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelClostridioides difficile
UniProt AccessionN/A

Clostridioides difficile

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Clostridioides difficile.

Review nameClostridioides difficile
OrganismClostridioides difficile
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC5084.0
KI10.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL126 6.96 IC50 110.0 Approved
CHEMBL3707376 6.42 IC50 380.0 Clinical
CHEMBL5639112 6.4 IC50 400.0 Preclinical
CHEMBL5561715 6.29 IC50 510.0 Preclinical
CHEMBL5527925 6.27 IC50 540.0 Preclinical
CHEMBL5555738 6.14 IC50 720.0 Preclinical
CHEMBL5562691 6.14 IC50 720.0 Preclinical
CHEMBL134293 6.08 IC50 840.0 Preclinical
CHEMBL5561884 6.02 IC50 950.0 Preclinical
CHEMBL5640011 6.0 IC50 1000.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
13
5.5
9
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LINEZOLID
CHEMBL126
Approved 2000
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,033
Total Assays
65
Tested Compounds
2
Assay Types
Functional — 1,030 assays, 65 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 995 52 5.2
assay format 35 13 4.9
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0 —
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine