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Target Snapshot

CHEMBL614998 Target Snapshot

H22 · CELL-LINE · Mus musculus

303Compounds
347Assays
5Approved Drugs
167.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H22 as ChEMBL target CHEMBL614998. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H22
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614998
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H22 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH22
UniProt AccessionN/A

H22

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as H22.

Review nameH22
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50162.0
EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4284150 8.1 IC50 8.0 Preclinical
CHEMBL498271 8.1 IC50 8.0 Preclinical
CHEMBL5624856 8.1 IC50 8.0 Preclinical
CHEMBL67 8.1 IC50 8.0 Preclinical
CHEMBL4280955 8.0 IC50 10.0 Preclinical
CHEMBL4288857 7.96 IC50 11.0 Preclinical
CHEMBL4790346 7.77 IC50 17.0 Preclinical
CHEMBL4854479 7.62 IC50 24.0 Preclinical
CHEMBL4866085 7.62 IC50 24.0 Preclinical
CHEMBL1592124 7.6 IC50 25.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
16
5.5
9
6.0
2
6.5
7
7.0
15
7.5
5
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
MITOXANTRONE
CHEMBL58
Approved 1987
Assay Landscape

Assay Landscape

347
Total Assays
131
Tested Compounds
3
Assay Types
Functional — 339 assays, 131 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 279 0
cell-based format 60 131 5.6
Toxicity — 5 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 1 6.7
organism-based format 1 0
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine