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Target Snapshot

CHEMBL614999 Target Snapshot

NCI-H647 · CELL-LINE · Homo sapiens

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39Compounds
14Assays
2Approved Drugs
22.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H647 as ChEMBL target CHEMBL614999. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H647
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614999
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H647 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H647
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H647
UniProt AccessionN/A

NCI-H647

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H647.

Review nameNCI-H647
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5022.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3128043 7.44 IC50 36.0 Preclinical
CHEMBL43 7.16 IC50 70.0 Approved
CHEMBL41700 7.1 IC50 80.0 Preclinical
CHEMBL44657 7.1 IC50 80.0 Approved
CHEMBL43453 6.92 IC50 120.0 Preclinical
CHEMBL4297458 6.36 IC50 441.0 Clinical
CHEMBL41526 6.27 IC50 540.0 Preclinical
CHEMBL38451 6.1 IC50 800.0 Preclinical
CHEMBL41701 6.02 IC50 950.0 Preclinical
CHEMBL291263 5.78 IC50 1680.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
4
5.5
4
6.0
1
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AMSACRINE
CHEMBL43
Approved 1987
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
17
Tested Compounds
1
Assay Types
Functional — 14 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 17 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine