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Target Snapshot

CHEMBL615002 Target Snapshot

Non-small cell lung cancer cell line · CELL-LINE

28Compounds
13Assays
3Approved Drugs
58.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Non-small cell lung cancer cell line as ChEMBL target CHEMBL615002. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Non-small cell lung cancer cell line
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL615002
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Non-small cell lung cancer cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNon-small cell lung cancer cell line
UniProt AccessionN/A

Non-small cell lung cancer cell line

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Non-small cell lung cancer cell line.

Review nameNon-small cell lung cancer cell line
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5058.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3353410 7.39 IC50 41.0 Approved
CHEMBL4285086 6.57 IC50 270.0 Preclinical
CHEMBL4288751 6.16 IC50 690.0 Preclinical
CHEMBL4278147 5.92 IC50 1200.0 Preclinical
CHEMBL4278841 5.82 IC50 1500.0 Preclinical
CHEMBL4278527 5.39 IC50 4100.0 Preclinical
CHEMBL4277811 5.28 IC50 5200.0 Preclinical
CHEMBL4277129 5.19 IC50 6500.0 Preclinical
CHEMBL4280622 5.17 IC50 6700.0 Preclinical
CHEMBL4293956 5.08 IC50 8400.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
3
5.5
1
6.0
1
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

OSIMERTINIB
CHEMBL3353410
Approved 2015
Assay Landscape

Assay Landscape

13
Total Assays
21
Tested Compounds
2
Assay Types
Functional — 12 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 21 4.7
organism-based format 4 0
ADME — 1 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 14 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine