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Target Snapshot

CHEMBL615024 Target Snapshot

U373 MG · CELL-LINE · Homo sapiens

391Compounds
121Assays
4Approved Drugs
252.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats U373 MG as ChEMBL target CHEMBL615024. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
U373 MG
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL615024
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether U373 MG still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelU373 MG
UniProt AccessionN/A

U373 MG

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as U373 MG.

Review nameU373 MG
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50248.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL322742 9.15 IC50 0.7 Preclinical
CHEMBL442020 8.7 IC50 2.0 Preclinical
CHEMBL170758 8.64 IC50 2.3 Preclinical
CHEMBL110742 8.3 IC50 5.0 Preclinical
CHEMBL217666 8.17 IC50 6.7 Preclinical
CHEMBL119700 8.15 IC50 7.0 Preclinical
CHEMBL124551 8.15 IC50 7.0 Preclinical
CHEMBL339527 8.1 IC50 8.0 Preclinical
CHEMBL16192 8.05 IC50 9.0 Preclinical
CHEMBL178993 8.05 IC50 9.0 Preclinical
Distribution

pChEMBL Value Distribution

54
5.0
5
5.5
22
6.0
17
6.5
37
7.0
16
7.5
11
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
TRIMETREXATE
CHEMBL119
Approved 1993
DOXORUBICIN
CHEMBL53463
Approved 1974
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

121
Total Assays
185
Tested Compounds
2
Assay Types
Functional — 118 assays, 185 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 118 185 6.2
ADME — 3 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 5 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine