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Evidence Snapshot

Poly [ADP-ribose] polymerase tankyrase-2

CHEMBL6154 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6154
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Poly [ADP-ribose] polymerase tankyrase-2 as ChEMBL target CHEMBL6154, mapped to UniProt Q9H2K2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Poly [ADP-ribose] polymerase tankyrase-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL6154
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9H2K2
Poly [ADP-ribose] polymerase tankyrase-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Poly [ADP-ribose] polymerase tankyrase-2 matters

As of 2026-09-14

Poly [ADP-ribose] polymerase tankyrase-2 is reviewed as Poly [ADP-ribose] polymerase tankyrase-2 (UniProt Q9H2K2); the current evidence base includes 5 approved drugs, 1079 compounds, and 164 assays, with lead potency reaching pChEMBL 10.0.

Protein context
Poly [ADP-ribose] polymerase tankyrase-2

Poly [ADP-ribose] polymerase tankyrase-2 Sequence length is 1166 aa.

Review this target as Poly [ADP-ribose] polymerase tankyrase-2, mapped to UniProt Q9H2K2. Sequence length is 1166 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9H2K2 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 5 approved drugs, 1079 compounds, and 164 assays for this target. The dominant activity type is IC50. CHEMBL4069447 is the current potency anchor at pChEMBL 10.0.

Use CHEMBL4069447 as the tractability anchor when discussing potency (pChEMBL 10.0).

Activity source · ChEMBL 36 via Core Engine
5 approved pChEMBL 10.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Poly [ADP-ribose] polymerase tankyrase-2 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9H2K2, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1079
Total Compounds
164
Total Assays
5
Approved Drugs
IC50: 1160.0, KI: 2.0, EC50: 9.0, KD: 30.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4069447
 10.0 IC50 —
No preferred name
CHEMBL3805393
 9.8 IC50 —
No preferred name
CHEMBL3806163
 9.8 IC50 —
No preferred name
CHEMBL3805896
 9.7 IC50 —
No preferred name
CHEMBL3804939
 9.7 IC50 —

Approved Drugs

Structure Compound First Approval
MIDOSTAURIN
CHEMBL608533
 2017
RUCAPARIB
CHEMBL1173055
 2016
OLAPARIB
CHEMBL521686
 2014
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6154