Poly [ADP-ribose] polymerase tankyrase-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O95271. Use UniProt O95271 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O95271 as the stable identity anchor, then attach disease evidence before program review.
Poly [ADP-ribose] polymerase tankyrase-1
Review this target as Poly [ADP-ribose] polymerase tankyrase-1, mapped to UniProt O95271. Sequence length is 1327 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Poly [ADP-ribose] polymerase tankyrase-1 as ChEMBL target CHEMBL6164, mapped to UniProt O95271. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Poly [ADP-ribose] polymerase tankyrase-1 is the right protein anchor across sources, using UniProt O95271 as the stable mapping.
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| Preferred Name | Poly [ADP-ribose] polymerase tankyrase-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O95271 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Poly [ADP-ribose] polymerase tankyrase-1 |
| UniProt Accession | O95271 |
| Component Type | Protein |
| Sequence Length | 1327 aa |
Poly [ADP-ribose] polymerase tankyrase-1
Review this target as Poly [ADP-ribose] polymerase tankyrase-1, mapped to UniProt O95271. Sequence length is 1327 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5989994 | 10.35 | IC50 | 0.045 | Preclinical |
| CHEMBL6052143 | 10.22 | IC50 | 0.0597 | Preclinical |
| CHEMBL5880126 | 10.19 | IC50 | 0.0647 | Preclinical |
| CHEMBL6059393 | 10.14 | IC50 | 0.0724 | Preclinical |
| CHEMBL5766123 | 10.05 | IC50 | 0.0891 | Preclinical |
| CHEMBL3110100 | 10.01 | IC50 | 0.0973 | Preclinical |
| CHEMBL5853920 | 10.01 | IC50 | 0.0979 | Preclinical |
| CHEMBL3110117 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL3110122 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5818177 | 9.97 | IC50 | 0.107 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 101 | 858 | 7.3 |
| cell-based format | 45 | 108 | 7.0 |
| assay format | 16 | 126 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 6.9 |
| cell-based format | 1 | 1 | 7.3 |