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Target Snapshot

CHEMBL6172 Target Snapshot

D-amino-acid oxidase · SINGLE PROTEIN · Sus scrofa

169Compounds
18Assays
0Approved Drugs
158.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P00371. Use UniProt P00371 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00371 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats D-amino-acid oxidase as ChEMBL target CHEMBL6172, mapped to UniProt P00371. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
D-amino-acid oxidase
SINGLE PROTEIN · Sus scrofa
As of 2026-09-13
ChEMBL target ID
CHEMBL6172
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00371
D-amino-acid oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether D-amino-acid oxidase is the right protein anchor across sources, using UniProt P00371 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD-amino-acid oxidase
UniProt AccessionP00371
Component TypeProtein
Sequence Length347 aa

D-amino-acid oxidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as D-amino-acid oxidase, mapped to UniProt P00371. Sequence length is 347 aa.

Mapped IDP00371
Review nameD-amino-acid oxidase
OrganismSus scrofa
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50143.0
KI2.0
KD13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5775595 7.26 IC50 55.0 Preclinical
CHEMBL5797729 7.26 IC50 55.0 Preclinical
CHEMBL5803179 7.26 IC50 55.0 Preclinical
CHEMBL5894625 7.26 IC50 55.0 Preclinical
CHEMBL5924045 7.26 IC50 55.0 Preclinical
CHEMBL5986892 7.26 IC50 55.0 Preclinical
CHEMBL6000679 7.26 IC50 55.0 Preclinical
CHEMBL6048421 7.26 IC50 55.0 Preclinical
CHEMBL146227 7.0 IC50 100.0 Preclinical
CHEMBL3805642 6.82 IC50 150.0 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
10
5.5
30
6.0
12
6.5
9
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

18
Total Assays
105
Tested Compounds
1
Assay Types
Binding — 18 assays, 105 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 15 78 5.7
tissue-based format 2 3 5.3
assay format 1 24 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine