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Target Snapshot

CHEMBL6174 Target Snapshot

Cytochrome c oxidase subunit 2 · SINGLE PROTEIN · Homo sapiens

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198Compounds
47Assays
5Approved Drugs
117.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P00403. Use UniProt P00403 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00403 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome c oxidase subunit 2 as ChEMBL target CHEMBL6174, mapped to UniProt P00403. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome c oxidase subunit 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6174
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00403
Cytochrome c oxidase subunit 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome c oxidase subunit 2 is the right protein anchor across sources, using UniProt P00403 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCytochrome c oxidase subunit 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP00403
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome c oxidase subunit 2
UniProt AccessionP00403
Component TypeProtein
Sequence Length227 aa

Cytochrome c oxidase subunit 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cytochrome c oxidase subunit 2, mapped to UniProt P00403. Sequence length is 227 aa.

Mapped IDP00403
Review nameCytochrome c oxidase subunit 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50114.0
KI1.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL122 7.7 IC50 20.0 Approved
CHEMBL42485 7.68 IC50 21.0 Preclinical
CHEMBL441414 7.58 IC50 26.0 Preclinical
CHEMBL254418 7.4 IC50 40.0 Preclinical
CHEMBL5568253 7.24 IC50 58.0 Preclinical
CHEMBL6 7.16 IC50 70.0 Approved
CHEMBL5565096 7.12 IC50 75.0 Preclinical
CHEMBL5568511 6.87 IC50 134.0 Preclinical
CHEMBL5568474 6.84 IC50 144.0 Preclinical
CHEMBL5653589 6.81 Kd 153.48 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
13
5.5
12
6.0
8
6.5
4
7.0
3
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ROFECOXIB
CHEMBL122
Approved 1999
Properties Compare Identifier
CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
INDOMETHACIN
CHEMBL6
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

47
Total Assays
77
Tested Compounds
3
Assay Types
Binding — 41 assays, 77 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 31 56 5.8
cell-based format 7 20 5.0
assay format 2 0 —
tissue-based format 1 1 6.5
ADME — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 0 —
cell-based format 1 0 —
Toxicity — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 2 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine