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Target Snapshot

CHEMBL6181 Target Snapshot

Envelope glycoprotein gp160 · SINGLE PROTEIN · Human immunodeficiency virus 1

23Compounds
20Assays
0Approved Drugs
5.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q72502. Use UniProt Q72502 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q72502 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Envelope glycoprotein gp160 as ChEMBL target CHEMBL6181, mapped to UniProt Q72502. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Envelope glycoprotein gp160
SINGLE PROTEIN · Human immunodeficiency virus 1
As of 2026-09-14
ChEMBL target ID
CHEMBL6181
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q72502
Envelope glycoprotein gp160
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Envelope glycoprotein gp160 is the right protein anchor across sources, using UniProt Q72502 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEnvelope glycoprotein gp160
UniProt AccessionQ72502
Component TypeProtein
Sequence Length854 aa

Envelope glycoprotein gp160

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Envelope glycoprotein gp160, mapped to UniProt Q72502. Sequence length is 854 aa.

Mapped IDQ72502
Review nameEnvelope glycoprotein gp160
OrganismHuman immunodeficiency virus 1
Assay Mix

Activity Type Distribution

IC503.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4281745 8.8 IC50 1.58 Preclinical
CHEMBL4289957 8.61 IC50 2.48 Preclinical
CHEMBL440999 6.68 IC50 209.4 Preclinical
CHEMBL5413691 6.17 Kd 670.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
1
6.5
0
7.0
0
7.5
0
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

20
Total Assays
4
Tested Compounds
1
Assay Types
Binding — 20 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 14 1 6.2
assay format 4 0
cell-based format 2 3 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine