Mitogen-activated protein kinase kinase kinase 19 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q56UN5. Use UniProt Q56UN5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q56UN5 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase 19
Review this target as Mitogen-activated protein kinase kinase kinase 19, mapped to UniProt Q56UN5. Sequence length is 1328 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 19 as ChEMBL target CHEMBL6191, mapped to UniProt Q56UN5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 19 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q56UN5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 19 |
| UniProt Accession | Q56UN5 |
| Component Type | Protein |
| Sequence Length | 1328 aa |
Mitogen-activated protein kinase kinase kinase 19
Review this target as Mitogen-activated protein kinase kinase kinase 19, mapped to UniProt Q56UN5. Sequence length is 1328 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL603469 | 9.28 | Kd | 0.52 | Clinical |
| CHEMBL388978 | 9.07 | Kd | 0.86 | Preclinical |
| CHEMBL4290597 | 8.92 | Kd | 1.2 | Preclinical |
| CHEMBL388978 | 8.73 | IC50 | 1.85 | Preclinical |
| CHEMBL1241674 | 8.29 | Kd | 5.1 | Preclinical |
| CHEMBL502835 | 8.28 | Kd | 5.2 | Approved |
| CHEMBL1908397 | 8.28 | Kd | 5.2 | Preclinical |
| CHEMBL1230609 | 8.26 | Kd | 5.5 | Clinical |
| CHEMBL4537673 | 8.02 | Kd | 9.6 | Preclinical |
| CHEMBL522892 | 7.92 | Kd | 12.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 90 | 67 | 6.9 |
| assay format | 30 | 5 | 7.4 |
| cell-based format | 5 | 1 | 5.5 |