Assay Detail
Functional
CHEMBL1000142
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Antiproliferative activity against human PC3 cells expressing EBP after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.50 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457722 | — | — | 1 | 7.89 |
| CHEMBL485729 | — | — | 1 | 7.71 |
| CHEMBL511857 | — | — | 1 | 7.64 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 7.59 |
| CHEMBL511507 | — | — | 1 | 7.43 |
| CHEMBL456435 | — | — | 1 | 7.42 |
| CHEMBL53325 | — | — | 1 | 7.42 |
| CHEMBL190883 | — | — | 1 | 7.33 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457722 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL485729 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL511857 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL511507 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL456435 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL53325 | — | Ki | = | 37.7 | nM | 7.42 |
| CHEMBL190883 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 86.9 | nM | 7.06 |