Compound Detail
CHEMBL305187
IFENPRODIL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL305187 |
| Name | IFENPRODIL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UYNVMODNBIQBMV-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
23
Targets
103
Activities
3
Assay Types
4
PK Parameters
20
Publications
4
Known Names
4
Indications
Molecular Properties
325.4
MW (Da)
3.77
ALogP
3
HBA
2
HBD
43.7
PSA (Ų)
0.88
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Cardiovascular Diseases Idiopathic Pulmonary Fibrosis Multiple Sclerosis, Relapsing-Remitting Severe Acute Respiratory Syndrome
ATC Classification
C04AX28
ifenprodil
Level 1: CARDIOVASCULAR SYSTEM
Level 2: PERIPHERAL VASODILATORS
Activity Summary
Ki 65 meas. best 8.99
IC50 35 meas. best 9.14
EC50 3 meas. best 6.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SH-SY5Y CHEMBL614910 | IC50 | 9.14 | 9.14 | 0.7 | 1 |
| Translocator protein CHEMBL4552 | IC50 | 9.14 | 9.14 | 0.7 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 8.99 | 7.1288 | 1.0 | 17 |
| Sigma non-opioid intracellular receptor 1 CHEMBL3602 | Ki | 8.7 | 8.505 | 2.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 8.64 | 7.491 | 2.3 | 10 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase CHEMBL5525 | Ki | 8.57 | 8.0333 | 2.7 | 6 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 8.41 | 8.41 | 3.9 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | Ki | 8.24 | 8.0267 | 5.8 | 9 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | Ki | 8.0 | 8.0 | 10.0 | 2 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | Ki | 7.96 | 7.74 | 11.0 | 5 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 7.88 | 7.118 | 13.3 | 5 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | IC50 | 7.7 | 7.605 | 20.0 | 4 |
| PC-3 CHEMBL390 | Ki | 7.59 | 7.59 | 25.8 | 1 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | IC50 | 7.18 | 6.7771 | 66.0 | 7 |
| Glutamate NMDA receptor; Grin1/Grin2b CHEMBL2096666 | IC50 | 7.14 | 7.14 | 73.0 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 7.01 | 7.01 | 98.0 | 12 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 7.0 | 6.98 | 100.0 | 2 |
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 6.84 | 6.84 | 143.2 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 6.69 | 6.2567 | 206.0 | 3 |
| 5-hydroxytryptamine receptor 1A CHEMBL3737 | IC50 | 6.62 | 6.62 | 238.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.6 | 6.3533 | 250.0 | 3 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.58 | 6.58 | 263.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL3446 | IC50 | 6.21 | 6.21 | 610.0 | 1 |
| Histamine H1 receptor CHEMBL231 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2C CHEMBL4109 | IC50 | 4.54 | 4.54 | 29100.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2A CHEMBL1972 | IC50 | 4.4 | 4.4 | 39500.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2D CHEMBL2591 | IC50 | 4.12 | 4.12 | 75900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.08333 | hr | Mus musculus |
| T1/2 | 0.01667 | hr | Rattus norvegicus |
| T1/2 | 0.08333 | hr | Homo sapiens |
| T1/2 | 4.818 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine