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Target Snapshot

CHEMBL614910 Target Snapshot

SH-SY5Y · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
5,631Compounds
2,935Assays
36Approved Drugs
2,148.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SH-SY5Y as ChEMBL target CHEMBL614910. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SH-SY5Y
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614910
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SH-SY5Y still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSH-SY5Y
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSH-SY5Y
UniProt AccessionN/A

SH-SY5Y

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SH-SY5Y.

Review nameSH-SY5Y
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

36
Approved
9
Phase III
13
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC501,732.0
EC50416.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2178785 9.68 IC50 0.21 Preclinical
CHEMBL9859 9.68 IC50 0.21 Preclinical
CHEMBL2178784 9.55 IC50 0.28 Preclinical
CHEMBL2178781 9.43 IC50 0.37 Preclinical
CHEMBL566757 9.3 IC50 0.5 Clinical
CHEMBL497451 9.28 IC50 0.52 Preclinical
CHEMBL188660 9.19 IC50 0.64 Preclinical
CHEMBL305187 9.14 IC50 0.73 Clinical
CHEMBL192786 8.85 IC50 1.4 Preclinical
CHEMBL460005 8.83 EC50 1.49 Preclinical
Distribution

pChEMBL Value Distribution

315
5.0
141
5.5
119
6.0
61
6.5
57
7.0
18
7.5
28
8.0
16
8.5
5
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

CERITINIB
CHEMBL2403108
Approved 2014
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
Properties Compare Identifier
MEMANTINE
CHEMBL807
Approved 2002
Properties Compare Identifier
GALANTAMINE
CHEMBL659
Approved 2001
Properties Compare Identifier
DONEPEZIL
CHEMBL502
Approved 1996
Properties Compare Identifier
DOCETAXEL ANHYDROUS
CHEMBL92
Approved 1995
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
PODOFILOX
CHEMBL61
Approved 1990
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
NICLOSAMIDE
CHEMBL1448
Approved 1982
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
NOVOBIOCIN
CHEMBL36506
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

2,938
Total Assays
1,070
Tested Compounds
3
Assay Types
Functional — 2,339 assays, 1,070 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2,335 1,070 5.5
organism-based format 4 0 —
ADME — 435 assays, 148 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 435 148 4.9
Toxicity — 164 assays, 79 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 164 79 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine